Rcinex Z(12tab)

Rcinex Z(12tab)

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Medicine : Rcinex Z(12tab)

Name:Rcinex Z(12tab)
Type:Tablet
Manufacturer:Lupin Laboratories Ltd
Generic Use:Isoniazid , Pyrazinamide , Rifampicin
Composition:Isoniazid(150mg) , Pyrazinamide(750mg) , Rifampicin(225mg)

Generic ( Isoniazid )


Typical use Of Isoniazid :Acute Leukemia, Mycobacterial Infection, Prophylaxis Of TB, Tuberculosis, Vestibular Disorders.
Mechanism of action of Isoniazid :Isoniazid Is A Prodrug And Must Be Activated By Bacterial Catalase. Specficially, Activation Is Associated With Reduction Of The Mycobacterial Ferric KatG Catalase-peroxidase By Hydrazine And Reaction With Oxygen To Form An Oxyferrous Enzyme Complex. Once Activated, Isoniazid Inhibits The Synthesis Of Mycoloic Acids, An Essential Component Of The Bacterial Cell Wall. At Therapeutic Levels Isoniazid Is Bacteriocidal Against Actively Growing Intracellular And Extracellular Mycobacterium Tuberculosis Organisms. Specifically Isoniazid Inhibits InhA, The Enoyl Reductase From Mycobacterium Tuberculosis, By Forming A Covalent Adduct With The NAD Cofactor. It Is The INH-NAD Adduct That Acts As A Slow, Tight-binding Competitive Inhibitor Of InhA.
Drug Interaction of Isoniazid :Your Doctor Or Pharmacist May Already Be Aware Of Any Possible Drug Interactions And May Be Monitoring You For Them. Do Not Start, Stop, Or Change The Dosage Of Any Medicine Before Checking With Your Doctor Or Pharmacist First.
Side effects of Isoniazid :Nausea, Vomiting, Tachycardia, Convulsions, Coma, Seizures, Urinary Retention, Dizziness, Hyperreflexia, Slurred Speech.

INTERACTIONS OF ISONIAZID


How Isoniazid will impact on Pregnancy ?

Information Not Available.

How Isoniazid will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Isoniazid

Information Not Available.




Generic ( Pyrazinamide )


Typical use Of Pyrazinamide :Tuberculosis.
Mechanism of action of Pyrazinamide :Pyrazinamide Has Bactericidal Action Against M. Tuberculosis In Acid Environment Present In Macrophages And Inflammed Tissue. Together With Rifampicin Provides Greatest Sterilising Action With Reduction In Relapse Rate. Reduces Tubular Secretion Of Uric Acid.
Drug Interaction of Pyrazinamide :Excretion May Be Blocked By Probenecid.
Side effects of Pyrazinamide :Anorexia, Fever, Malaise, Arthralgia, Nausea And Vomiting.

INTERACTIONS OF PYRAZINAMIDE


How Pyrazinamide will impact on Pregnancy ?

Information Not Available.

How Pyrazinamide will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Pyrazinamide

Information Not Available.




Generic ( Rifampicin )


Typical use Of Rifampicin :Epilepsy (monotherapy), Iron-deficiency Anaemia With Chronic Renal Failure, Leprosy, Meningitis, Meningitis Prophylaxis, Mycobacterial Infection, Paget's Disease Of Bone, Tuberculosis, Urinary Tract Infection
Mechanism of action of Rifampicin :Rifampicin Acts Via The Inhibition Of DNA-dependent RNA Polymerase, Leading To A Suppression Of RNA Synthesis And Cell Death.
Drug Interaction of Rifampicin :Epilepsy (monotherapy), Iron-deficiency Anaemia With Chronic Renal Failure, Leprosy, Meningitis, Meningitis Prophylaxis, Mycobacterial Infection, Paget's Disease Of Bone, Tuberculosis, Urinary Tract Infection
Side effects of Rifampicin :Nausea, Vomiting, Anorexia, Abdominal Discomfort, Orange Coloration Of Secretions.

INTERACTIONS OF RIFAMPICIN


How Rifampicin will impact on Pregnancy ?

Information Not Available.

How Rifampicin will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Rifampicin

Information Not Available.




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