Insuman Comb(25)

Insuman Comb(25)

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Medicine : Insuman Comb(25)

Name:Insuman Comb(25)
Type:Injection
Manufacturer:Sanofi India Ltd (aventis)
Generic Use:Insulin Lispro Protamine , Insulin Lispro
Composition:Insulin Lispro Protamine(75%) , Insulin Lispro(25%)

Generic ( Insulin Lispro Protamine )


Typical use Of Insulin Lispro Protamine :Diabetes Mellitus.
Mechanism of action of Insulin Lispro Protamine :Insulin Lispro Protamine Binds To The Insulin Receptor (IR), A Heterotetrameric Protein Consisting Of Two Extracellular Alpha Units And Two Transmembrane Beta Units. The Binding Of Insulin To The Alpha Subunit Of IR Stimulates The Tyrosine Kinase Activity Intrinsic To The Beta Subunit Of The Receptor. The Bound Receptor Autophosphorylates And Phosphorylates Numerous Intracellular Substrates Such As Insulin Receptor Substrates (IRS) Proteins, Cbl, APS, Shc And Gab 1. Activation Of These Proteins Leads To The Activation Of Downstream Signaling Molecules Including PI3 Kinase And Akt. Akt Regulates The Activity Of Glucose Transporter 4 (GLUT4) And Protein Kinase C (PKC).
Drug Interaction of Insulin Lispro Protamine :Insulin Lispro Protamine Is Known To Interact With Other Drugs Like Corticosteroids, Isoniazid, Certain Lipid-lowering Drugs, Oestrogens, Oral Contraceptives, Phenothiazines, Sulfa Antibiotics, Certain Antidepressants (MAOIs), ACE Inhibitors, Angiotensin II Receptor Blocking Agents, ?-adrenergic Blockers, Octreotide And Alcohol.
Side effects of Insulin Lispro Protamine :Redness, Swelling, Itching At The Site Of Inj, Lipodystrophy, Pruritus And Rash.

INTERACTIONS OF INSULIN LISPRO PROTAMINE


How Insulin Lispro Protamine will impact on Pregnancy ?

Information Not Available.

How Insulin Lispro Protamine will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Insulin Lispro Protamine

Information Not Available.




Generic ( Insulin Lispro )


Typical use Of Insulin Lispro :Insulin Dependent Diabetes Mellitus.
Mechanism of action of Insulin Lispro :Insulin Lispro Binds To The Insulin Receptor (IR), A Heterotetrameric Protein Consisting Of Two Extracellular Alpha Units And Two Transmembrane Beta Units. The Binding Of Insulin To The Alpha Subunit Of IR Stimulates The Tyrosine Kinase Activity Intrinsic To The Beta Subunit Of The Receptor. The Bound Receptor Autophosphorylates And Phosphorylates Numerous Intracellular Substrates Such As Insulin Receptor Substrates (IRS) Proteins, Cbl, APS, Shc And Gab 1. Activation Of These Proteins Leads To The Activation Of Downstream Signaling Molecules Including PI3 Kinase And Akt. Akt Regulates The Activity Of Glucose Transporter 4 (GLUT4) And Protein Kinase C (PKC). Hexamers Of Insulin Lispro Are Produced In The Presence Of Zinc And M-cresol. These Weakly Associated Hexamers Quickly Dissociate Upon Subcutaneous Injection And Are Absorbed As Monomers Through Vascular Endothelial Cells. These Properties Give Insulin Lispro Its Fast-acting Properties.
Drug Interaction of Insulin Lispro :Insulin Lispro Is Known To Interact With Other Drugs Like Alcohol, Amitriptyline (HCl), Aspirin, Chlordiazepoxide (HCl), Chlorpromazine (HCl), Diazoxide, Diltiazem (HCl), Disopyramide, Fenfluramine (HCl), Guanethidine, Lithium, Mebendazole, Nifedipine, Octreotide (Acetate). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Insulin Lispro :Hypoglycemia, Lipoatrophy, Allergic Reactions, Swelling Of Feet.

INTERACTIONS OF INSULIN LISPRO


How Insulin Lispro will impact on Pregnancy ?

Information Not Available.

How Insulin Lispro will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Insulin Lispro

Information Not Available.




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