Dolentia Gel(30gm)

Dolentia Gel(30gm)

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Medicine : Dolentia Gel(30gm)

Name:Dolentia Gel(30gm)
Type:Gel
Manufacturer:Akumentis Healthcare Ltd
Generic Use:Capsaicin , Diclofenac Potassium , Methyl Salicylate , Menthol
Composition:Capsaicin(0.025 % W/w) , Diclofenac Potassium(1 % W/w) , Methyl Salicylate(5 % W/w) , Menthol(5 % W/w)

Generic ( Capsaicin )


Typical use Of Capsaicin :Treat Minor Aches And Pains Of The Muscles/joints (e.g., Arthritis, Backache, Sprains), Nerve Pain.
Mechanism of action of Capsaicin :Capsaicin Binds To A Receptor Called The Vanilloid Receptor Subtype 1 (VR1). VR1, Which Can Also Be Stimulated With Heat And Physical Abrasion, Permits Cations To Pass Through The Cell Membrane And Into The Cell When Activated. The Resulting Depolarization Of The Neuron Stimulates It To Signal The Brain.
Drug Interaction of Capsaicin :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Capsaicin :Rash, Itching/swelling (especially Of The Face/tongue/throat), Severe Dizziness, Trouble Breathing, Warmth, Stinging, Or Burning On The Application Site May Occur.

INTERACTIONS OF CAPSAICIN


How Capsaicin will impact on Pregnancy ?

Information Not Available.

How Capsaicin will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Capsaicin

Information Not Available.




Generic ( Diclofenac Potassium )


Typical use Of Diclofenac Potassium :Adnexitis, Dysmenorrhoea, Inflammation, Migraine, Post-operative Pain, Post-traumatic Pain, Rheumatoid Arthritis.
Mechanism of action of Diclofenac Potassium :Diclofenac Potassium Inhibits Both Leukocyte Migration And The Enzyme Cylooxygenase (COX-1 And COX-2), Leading To The Peripheral Inhibition Of Prostaglandin Synthesis. As Prostaglandins Sensitize Pain Receptors, Inhibition Of Their Synthesis Is Responsible For The Analgesic Effects Of Diclofenac. Antipyretic Effects May Be Due To Action On The Hypothalamus, Resulting In Peripheral Dilation, Increased Cutaneous Blood Flow, And Subsequent Heat Dissipation.
Drug Interaction of Diclofenac Potassium :Diclofenac Potassium Is Known To Interact With Other Drugs Like Cholestyramine, Colestipol (HCl), Cyclosporin A, Misoprostol, Nitrendipine, Sucralfate. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Diclofenac Potassium :Dizziness, Vertigo, Headache, Rashes, GI Upset, Elevation Of Liver Enzymes, GI Hemorrhage, Vision Disturbances, Erythema Multiforme.

INTERACTIONS OF DICLOFENAC POTASSIUM


How Diclofenac Potassium will impact on Pregnancy ?

Information Not Available.

How Diclofenac Potassium will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Diclofenac Potassium

Information Not Available.




Generic ( Methyl Salicylate )


Typical use Of Methyl Salicylate :Musculoskeletal Disorders, Peripheral Vascular Disease, Respiratory Tract Infections, Soft Tissue Disorders.
Mechanism of action of Methyl Salicylate :Methyl Salicylate Is Considered A Non-selective COX Inhibitor√ā¬Ěthat Is, It Inhibits Two Isoforms Of Cyclooxygenase, COX-1 And COX-2. The Analgesic, Antipyretic, And Anti-inflammatory Activity Of NSAIDs Appears To Be Achieved Mainly Through Inhibition Of COX-2, Whereas Inhibition Of COX-1 Would Be Responsible For Unwanted Effects On Platelet Aggregation And The Gastrointestinal Tract. Methyl Salicylate Directly And Irreversibly Inhibits The Activity Of Both Types Of Cyclo-oxygenases (COX-1 And COX-2) To Decrease The Formation Of Precursors Of Prostaglandins And Thromboxanes From Arachidonic Acid. Salicylate May Competitively Inhibit Prostaglandin Formation. Salicylate's Antirheumatic (nonsteroidal Anti-inflammatory) Actions Are A Result Of Its Analgesic And Anti-inflammatory Mechanisms.
Drug Interaction of Methyl Salicylate :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Methyl Salicylate :Irritative Skin Reactions, Skin Ulcers, Stinging Of Skin.

INTERACTIONS OF METHYL SALICYLATE


How Methyl Salicylate will impact on Pregnancy ?

Information Not Available.

How Methyl Salicylate will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Methyl Salicylate

Information Not Available.




Generic ( Menthol )


Typical use Of Menthol :Pharmaceutical Aid
Mechanism of action of Menthol :Menthol Primarily Activates The Cold-sensitive TRPM8 Receptors In The Skin. Menthol, After Topical Application, Causes A Feeling Of Coolness Due To Stimulation Of 'cold' Receptors By Inhibiting Ca++ Currents Of Neuronal Membranes. It May Also Yield Analgesic Properties Via Kappa-opioid Receptor Agonism.
Drug Interaction of Menthol :Menthol Is Known To Interact With Other Drugs Like Alcohol. These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Menthol :Nystagmus, Contact Dermatitis, Apnea. Menthol Produces Potentially Life-threatening Effects Which Include Coma. Overdosage Of Menthol Include Irregularities In Heart Rhythm. The Symtomatic Adverse Effects Produced By Menthol Such As Vertigo, Drowsiness, Ataxia, Abdominal Pain, Nausea And Vomiting.

INTERACTIONS OF MENTHOL


How Menthol will impact on Pregnancy ?

Information Not Available.

How Menthol will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Menthol

Information Not Available.




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